Comparison of two different dosages of the tranexamic acid on reducing of bleeding during spinal fusion surgery

Background: One of the problems that influenced surgeon and anesthesiologist in strumental spinal fusion surgery (CD surgery) is the excessive bleeding during surgery. There are different ways for reducing bleeding during surgery such as the intravenous administration of tranexamic. In this study the effect of two doses of tranexamic acid for reducing of bleeding in spinal fusion surgery was evaluated.

Methods: This clinical trial study was performed on 75 patients with class I and II ASA patients scheduled for strumental spinal fusion surgery under the same general anesthesia. The patient’s randomly divided into 3 groups. One group received single dose of tranexamic acid and another group received single dose of tranexamic acid plus maintenance dose of tranexamic acid that continued during surgery and the control group received normal saline as a placebo. The blood loss during surgery and until 24 hours later was documented. Bleeding score and surgeon satisfaction scores were recorded.

Results: The amount of blood loss was reduced in both groups receiving the tranexamic acid (934 cc in control group, 664cc in single dose group and 758 cc in single dose plus maintenance dose group). But the difference was not statistically significant. (P value>0.05).

Conclusion: The quality of surgery field, surgeon satisfaction scores and blood transfusion to patients in 3 groups was not significantly different.