The Relationship between Oral Microbiome and SARS-CoV-2

The oral microbiome represents an important part of the human microbiome. It has an important function to protect against the colonization of extrinsic bacteria, affecting systemic health. On the other hand, the most common oral diseases such as caries, gingivitis, and periodontitis, are based on microorganisms. After the gut microbiome, the oral microbiome is the second largest microbial population in the body. It has the potential to affect the onset and progression of a variety of localized and systemic disorders, including viral infections, especially those that enter the body through the oropharynx. Pandemics like SARS and coronavirus disease 2019 (COVID-19) have impacted negatively on economies and people around the world in recent years, making viral infection one of the most common and dangerous health problems. Despite being one of many respiratory viruses that use the oropharynx as their primary replication site, the novel pandemic human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19 disease has yet to be determined. PubMed, Medline, Google Scholar, Science Direct, Scopus, and Web of Science databases were among the search engines used up to December 1, 2021. For published data, search terms included 'Microbiome', 'COVID-19,' ' Oral Microbiome changes in COVID-19,' dysbiosis in COVID-19', or 'SARS-CoV-2'. This concise review aimed to see if there was a link between the oral microbiome and SARS-CoV-2.