INFLUENCE OF C-TERMINAL TELOPEPTIDE OF TYPE I COLLAGEN AT LINEAR AND VOLUMETRIC CHARACTERISTICS OF LEFT VENTRICLE IN PATIENTS WITH CHRONIC HEART FAILURE

In this study linear and three-dimensional left ventricle characteristic de-pending on the level of C-terminal telopeptide of type I collagen of 112 ischemic chronic heart failure patients with preserved and reduced systolic function have been studied and analyzed. The dynamics of the main clinical symptoms, indicators of structural and functional heart status according doppler-echokardioskopy and the level of C-terminal telopeptide of type I collagen were evaluated. As a result of this work we revealed a connection between interstitial type I collagen degradation process and remodeling of the left ventricle in patients with chronic heart failure.