STUDY OF EFFECT PREKONDITSIONIRUYUSCHEGO RESVERATROL AND NICORANDIL IN THE CORRECTION OF ADMA-LIKE PRE-ECLAMPSIA

The search for new drugs have prekonditsioniruyuschimi properties is a promising direction of modern pharmacology. We investigated the role of prekonditsioniruyuschih properties of resveratrol and nicorandil in the correction of ADMA-like pre-eclampsia. Keeping resveratrol (2 mg/kg) and nicorandil (2x10 mg/kg) led to a marked correction of morphological and functional disorders arise in modeling experimental preeclampsia. Concomitant administration of a blocker of K+ ATP-channels -glibenclamide (50 mg/kg) with the test drugs practically eliminate protective effects of resveratrol and nicorandil. These data suggest a significant role prekonditsioniruyuschih properties of resveratrol and nicorandil in the implementation of the positive effects of the correction of morphological and functional disorders arise when modeling ADMA-like pre-eclampsia.