The Effect of Inducers and Inhibitors of Monooxygenase on the Activity Nitrergic System in the Microsomes in the Ischemic Liver

Experiments were carried out on 62 white male rats and average weighing was 180-220 g. We found that inducers and inhibitors of monooxygenase showed opposite effects on the activity of NOS in the ischemic liver microsomes. Benzonal and cimetidine, after 1 night of their introduction, had no significant effect on all studied parameters. After 3 and 10 daily using drug metabolism inducer that benzonal makes a slow speed nitrate reductase system, stimulates nitroxylenes system (eNOS), and cimetidine, on the contrary – even more nitrate reductase activates the speed system, inhibits eNOS nitroxylenes. Now, in connection with the growth of liver disease and aggressive exposure to xenobiotic with induction and inhibitory action, this problem acquires a special urgency and, surely, requires further study.