Influence of Vitamin D Level on Diabetic Dyslipidemia

Background: Vitamin D deficiency is greater than expected all over the world and it is linked to many health and disease conditions.

Aim of the Work: Our work aimed to study the relation between serum level of vitamin D 25( OH ) and lipid parameters.

Patients and Methods: This study included 176 participants 88 patients with type 2 diabetes mellitus and 88 clinically healthy volunteers age and sex matched persons with normal glycated hemoglobin as a control group and their age ranged from 30 to 60 years old. A full history and clinical examination were done for both patients and control group. Fasting samples (12hrs) for lipid parameters including total cholesterol, triglycerides, (HDL) and (LDH), serum 25 (OH) vitamin D level ,fasting blood sugar and 2 hour postprandial and (HbA1c).

Results: In this study 71 patients had vitamin D deficiency (80.7%) and 17(19.3%) patients had either vitamin D insufficiency or sufficiency. Compared to the control group which showed that 38 persons had deficient vitamin D (43.2%) and 50 (56.8%) had either vitamin D insufficiency or sufficiency, which demonstrate that there were high statistical significance difference between case and controls regarding to 25(OH)D with p-value <0.001. Although in diabetic patients with vitamin D deficiency, serum levels of total cholesterol, TG, and LDL were higher and HDL was lower compared to patients with vitamin D sufficiency, this association was statistically significant for serum level of TG (237.3 ± 120.9 vs. 186.3 ± 77.0), and HDL (33.5 ± 6.4 vs. 40.4 ± 13.2), with P=0.037 and 0.003, respectively. Also in the control group there was a statistically significant difference between participants with vitamin D deficiency when compared to those without regarding the mean values of triglycerides (257.4 ± 106.2 vs. 155.8 ± 108.9), and HDL (30.7 ± 10.1 vs. 44.3 ± 15.5), with P<0.0001. This study also revealed that there was a negative statistically significant correlation between vitamin D level and HbA1C (P=0.035) in diabetic group.

Conclusions: The results of the present study showed that serum concentrations of 25(OH) D were inversely associated with high TG and low HDL in both diabetics and control groups.