Mesenchymal Stem Cell-Based Therapy for Stroke: Current Understanding and Challenges

Li, Weifeng and Shi, Linli and Hu, Bei and Hong, Yimei and Zhang, Hao and Li, Xin and Zhang, Yuelin (2021) Mesenchymal Stem Cell-Based Therapy for Stroke: Current Understanding and Challenges. Frontiers in Cellular Neuroscience, 15. ISSN 1662-5102

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Abstract

Stroke, the most prevalent cerebrovascular disease, causes serious loss of neurological function and is the leading cause of morbidity and mortality worldwide. Despite advances in pharmacological and surgical therapy, treatment for functional rehabilitation following stroke is limited with a consequent serious impact on quality of life. Over the past decades, mesenchymal stem cell (MSCs)-based therapy has emerged as a novel strategy for various diseases including stroke due to their unique properties that include easy isolation, multipotent differentiation potential and strong paracrine capacity. Although MSCs have shown promising results in the treatment of stroke, there remain many challenges to overcome prior to their therapeutic application. In this review, we focus on the following issues: the scientific data from preclinical studies and clinical trials of MSCs in the treatment of stroke; the potential mechanisms underlying MSC-based therapy for stroke; the challenges related to the timing and delivery of MSCs and MSC senescence.

Item Type: Article
Subjects: East Asian Archive > Medical Science
Depositing User: Unnamed user with email support@eastasianarchive.com
Date Deposited: 18 May 2023 06:51
Last Modified: 24 Jun 2024 05:26
URI: http://library.eprintdigipress.com/id/eprint/807

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